Upon removal of 4th leg, grasshopper goes deaf

My endocrinologist is puzzled by the fact that sometimes, when she increases my dosage of testosterone (which I do not naturally produce enough of), my blood level of it actually decreases.  I thought I’d check if possibly there was some odd interaction between other medicines I take and the testosterone.  One study looked promising – until I read the absolutely unbelievable details, which suggest that researchers will put any dosage of a drug they want into a test animal to prove their point.

From PubMed:

In the first of two experiments, young male cardiomyopathic hamsters were injected intraperitoneally twice a day for 29 days with 8 mg alprazolam/kg body weight or saline. Three hours after the same injections on day 30, they were sacrificed and plasma hormone levels were measured. Alprazolam increased cortisol, total glucocorticoid and triiodothyronine levels…These experiments suggest that chronic benzodiazepine treatment can affect adrenocortical function and perhaps some aspects of thyroid function.”

8 mg/kg body weight twice a day?  These experiments suggest that researchers at the VA Medical Center in E. Orange, NJ, need to move into the world of reality.  These people could make a good case against ingestion of dihydrogen monoxide.  For a 180 pound human (81.5 kg) to get an equivalent dose, that person would have to take over 1300 mg alprazolam per day (or more, for equivalent bioavailability peroral.)

I guess I’m safe at 2 mg/day.

Leave Georgia, pretty please, Czar Putin

My grandfather, the late Andrzhei Antonovich Dzialtvo, fled Lithuania with his family around 1902, when he was about four years of age.  It was during one of Russia’s periodic invasions of countries around it, which Russia has engaged in as a regular hobby long before Europe even noticed the Americas existed.

It’s also long-known that asking the Czar – whatever he goes by, Czar, General Secretary,  President, or Prime Minister – to stop invading gives the guy a good belly laugh.

So this is what I’ve suggested by phone to my Congressional Representative, the Hon. Christopher H. Smith (R4-NJ), and one of my Senators, the Hon. Frank Lautenberg (D-NJ), in a call made to each of their offices:

• The President of the United States of America should immediately recall his ambassador from Moscow and reduce relations to a chargé d’affaires level;
• The State Department of the United States of America should issue a warning to all American citizens in Russia to promptly leave Russia;
• The President of the United States of America should, by Executive Order, immediately declare a suspension of all trade with the Russian Republic.

That will get Vladimir Putin’s attention.  Calling for meetings and asking politely has not worked for dealings with Russia in over a millennium, and it obviously is not going to work now.

When I called Rep. Smith’s office, I was told that the Congress couldn’t do anything because Speaker Pelosi has declared a recess; I pointed out that the Representative was quite good at holding press conferences and could issue a public statement calling for these measures from the executive branch of the US government.  Senator Lautenberg’s office was a little more encouraging, and the staffer had a good laugh when I told him about Rep. Smith’s staffer trying to blame Speaker Pelosi for a possible inability for Rep. Smith to say anything publicly.

This is going to make it an interesting Olympic season, too…

Waning Moon

From full she darkens, failing, fading
Remembers climb and zenith, her creation
Twained moons they brighten, building, waxing
Reflected trine light, still needs but one

Still yet she dims, should she not shun
A final journey of making new
If ‘twould be ‘complished, must now she run
And claim Creatrix days, hers now so few

The matrix closes dry as the dew
To leave the Twain to grow alone
“No!” she cries, “Not only two
“‘gain I will birth the flesh, the bone!”

Fervored glories not unbecoming she who as a Goddess
Passion’d pains forthgiving: another yet to bless.